GMP-Creative Biolabs provides one-stop customer-oriented services including biopharmaceutical contract R&D, process development, cGMP manufacturing, QA & QC solutions for scientific research, preclinical, clinical and commercial supply. We proceed your projects according to your specific demands in quality, timeline and budget, supporting researchers across different therapeutic areas. Clear, open and regular communication with customers is as important to our success as our in-depth scientific knowledge. more
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Creative Biolabs offers a full range of upstream and downstream service packages of in vivo ascites production and in vitro cell culture production of monoclonal antibodies following strict cGMP guidelines. Customizable and cost-effective service is available for scale-up cGMP production of monoclonal antibodies from hybridoma cells.
Services Available:
In Vivo Monoclonal Antibody Production through Mouse Ascites
• Mycoplasma testing and decontamination of hybridoma cell lines
• Multiple strains available(including BALB/c, BALB/c hybrid, Nude and SCID mice)
• Ascites fluid develops in around 2 weeks
• 3-5ml of ascites per mouse with an antibody concentration of ~3-10mg/ml
• Downstream purification of ascites fluid
• Typical turnaround time of 5-8 weeks
• Over 5,000 mice capacity (high lot-to-lot consistency)
• Multi-kilogram quantities of mAb
• Liters of ascites
• Batch record with complete information.
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In Vitro Monoclonal Antibody Production through Cell Culture Methods
• Free of endogenous mouse antibodies
• Yield optimization and scale-up production
• Adaption to serum free media
• Multiple production system(spinner flasks, roller bottles, bioreactors)
• 15-50 mg/L for antibody production in vitro
• Downstream purifications
• Multi-gram quantities of high-quality mAb
• Corresponding CHO stable cell line construction
To discuss your Hybridoma based Manufacture Service demands or to request a proposal, please contact us.
For Research Use Only. Not For Clinical Use.